Hair Loss Treatment

Hair loss treatment blog Hair Loss treatment blog at drproctor.com

Hair loss treatment blog at peterproctor.com

Hair loss blog at nitrone.com

Hair loss treatment blog at gohair.com

Hair loss treatment blog at hair-loss-treatment.com

Hair loss blogs at centpharm.com

J Dtsch Dermatol Ges. 2011 Oct;9 Suppl 6:S1-57. doi: 10.1111/j.1610-0379.2011.07802.x.

Evidence-based (S3) guideline for the treatment of androgenetic alopecia in women and in men.

Blumeyer A, et al

Abstract

Androgenetic alopecia is the most common hair loss disorder, affecting both men and women. Initial signs of androgenetic alopecia usually develop during teenage years leading to progressive hair loss with a pattern distribution. Moreover, its frequency increases with age and affects up to 80 % Caucasian men and 42 % of women. Patients diagnosed with androgenetic alopecia may undergo significant impairment of quality of life. Despite the high prevalence and the variety of therapeutic options available, there have been no national or international evidence-based guidelines for the treatment of androgenetic alopecia in men and women so far. Therefore, the European Dermatology Forum (EDF) initiated a project to develop an evidence-based S3 guideline for the treatment of andro-genetic alopecia. Based on a systematic literature research the efficacy of the currently available therapeutic options was assessed and therapeutic recommendations were passed in a consensus conference. The purpose of the guideline is to provide dermatologists as well as general practitioners with an evidence-based tool for choosing an efficacious and safe therapy for patients with hair los due to androgenetic alopecia.

J Dtsch Dermatol Ges. 2011 Feb 2.

Current standards in the diagnostics and therapy of hair diseases - hair consultation.
Blume-Peytavi U, Vogt A.

Competence Center for Hair and Hair Diseases, Clinical Research Center for Hair and Skin Science, Department of Dermatology and Allergy, Charité Universitätsmedizin, Berlin, Germany.

Abstract
Hair and scalp diseases present an extensive diagnostic and therapeutic task. Treating them is often a challenge for the physician in daily practice. Unclear diagnoses, chronic conditions with long-lasting therapies and the uncertainty of the patient may often lead to unsatisfying situations for both the patient as well as the doctor. The complaints can be divided into (1) hair loss, (2) increased hair growth and (3) abnormal hair quality. A structured history and the objectification of the clinical findings with the help of standardized diagnostic methods and score systems or classifications enable a diagnosis in most patients already at the first visit. Moreover, such structured processes strengthen the treatment satisfaction and compliance of both the patient and the therapist. In the meantime, diagnostic measures and clinical practice guidelines are available for the most common hair disorders. Expertise in basic psychosomatic care and an empathetic approach to the fears and concerns as well as practical advice for the daily contact with hair disorders should be integrated as separate elements in the management of hair diseases; in most cases they are gratefully welcomed by the patients. The aim of this article is to provide the physician with a guideline for the structured management of a hair patient. An overview of recent new developments and the currently available clinical practice guidelines for diagnosis and therapy of hair disorders is presented.

Keywords: hair loss hair loss treatment hair rebrowth blog

Hair Loss Treatment

Exp Dermatol. 2010 Aug;19(8):e347-9.

An unexpected twist in alopecia areata pathogenesis: are NK cells protective and CD49b+ T cells pathogenic?
Kaufman G, et al

Abstract
Natural killer (NK) cells have become a recent focus of interest in alopecia areata (AA) research. To further investigate their role in an established mouse model of hair loss due to alopecia areata, lesional skin from older C3H/HeJ mice with AA was grafted to young C3H/HeJ female mice, and NK cells were depleted by continuous administration of rabbit anti-asialo GM1. As expected, this significantly reduced the number of pure NK cells in murine skin, as assessed by NKp46 quantitative immunohistochemistry. Quite unexpectedly, however, the onset of hair loss in C3H/HeJ mice was accelerated, rather than retarded. NK cell depletion was accompanied by a significant increase in the number of perifollicular CD49b+T cells in the alopecic skin of anti-asialo GM1-treated mice. These findings underscore the need to carefully distinguish in future AA research between pure NK cells and defined subsets of CD49b+ lymphocytes, as they may exert diametrically opposed functions in hair follicle immunology and immunopathology.

J Drugs Dermatol. 2010 May;9(5):537

Alopecia: botanical approaches in review.
Abdullah F, Rashid RM.

The Morzak Clinic, Carolina, Puerto Rico.

Abstract
The use of herbal medications in the treatment of dermatologic disease is common practice among consumers. In this paper, the authors review the botanical modalities in the literature with a particular focus on various presentations of hair loss. To maximize potential clinical application, this review has been limited human studies. The goal of the study is to a thorough evaluation of the current understanding of the use of non-pharmaceutical botanical products in the management of hair loss.

modified for hair loss treatment blog

Ann Dermatol. 2009 May; 21(2): 142–146.

Copyright © 2009 Korean Dermatological Association; The Korean Society for Investigative Dermatology
The Therapeutic Effect and the Changed Serum Zinc Level after Zinc Supplementation in Alopecia Areata Patients Who Had a Low Serum Zinc Level
Hoon Park, et al

Edited for hair oss blog

Abstract

It has been reported that some alopecia areata patients have zinc deficiency. There have also been several reports published concerning oral zinc sulfate therapy, with encouraging results, in some alopecia areata patients.Objective
The purpose of this study was to evaluate the therapeutic effects of oral zinc supplementation for twelve weeks in alopecia areata patients who had a low serum zinc level.

Methods
Oral zinc gluconate (50 mg/T/day) supplementation was given to alopecia areata patients without any other treatment for twelve weeks. The serum zinc level was measured before and after zinc supplementation. A four-point scale of hair regrowth was used to evaluate the therapeutic effect of oral zinc supplementation in these patients.

Results

Fifteen alopecia areata patients were enrolled in this study. After the therapy, the serum zinc levels increased significantly from 56.9 µg/ to 84.5 µg/dl. Positive therapeutic effects were observed for 9 out of 15 patients (66.7%) although this was not statistically significant. The serum zinc levels of the positive response group increased more than those of the negative response group (p=0.003).

1. Carruthers R. Post-partum alopecia and zinc. Med J Aust. 1983;2:259. [PubMed]
2. Arnaud J, Beani JC, Favier AE, Amblard P. Zinc status in patients with telogen defluvium. Acta Derm Venereol. 1995;75:248–249. [PubMed]
3. Camacho FM, Garcia-Hernandez MJ. Zinc aspartate, biotin, and clobetasol propionate in the treatment of alopecia areata in childhood. Pediatr Dermatol. 1999;16:336–338. [PubMed]
4. Slonim AE, Sadick N, Pugliese M, Meyers-Seifer CH. Clinical response of alopecia, trichorrhexis nodosa, and dry, scaly skin to zinc supplementation. J Pediatr. 1992;121:890–895. [PubMed]
5. Wolowa F, Jablonska S. Zinc in the treatment of alopecia areata. In: Kobori T, Montagna W, Toda K, editors. Biology and disease of the hair. 2nd ed. Tokyo: University of Tokyo Press; 1976. pp. 305–308.
6. Plonka PM, Handjiski B, Popik M, Michalczyk D, Paus R. Zinc as an ambivalent but potent modulator of murine hair growth in vivo-preliminary observations. Exp Dermatol. 2005;14:844–853. [PubMed]
7. Lee SY, Nam KS, Seo YW, Lee JS, Chung H. Analysis of serum zinc and copper levels in alopecia areata. Ann Dermatol. 1997;9:239–241.
8. Weismann K, Hagdrup HK. Hair changes due to zinc deficiency in a case of sucrose malabsorption. Acta Derm Venereol. 1981;61:444–447. [PubMed]
9. Hong SP, Jeon SY, Oh TH, Lee WS. A retrospective study of the effect of superficial cryotherapy on alopecia areata. Korean J Dermatol. 2006;44:274–280.
10. Tak WJ, Chung YS, Ro BI. A clinical study on alopecia areata (1996-2000)(TGF-VI). Korean J Dermatol. 2002;40:791–800.
11. Tasaki M, Hanada K, Hashimoto I. Analyses of serum copper and zinc levels and copper/zinc ratios in skin diseases. J Dermatol. 1993;20:21–24. [PubMed]
12. Malanin K, Telegdy E, Qazaq H. Hair loss and serum zinc values among Arab females in Al Ain region, United Arab Emirates. Eur J Dermatol. 2007;17:446–447. [PubMed]
13. Mussalo-Rauhamaa H, Lakomaa EL, Kianto U, Lehto J. Element concentrations in serum, erythrocytes, hair and urine of alopecia patients. Acta Derm Venereol. 1986;66:103–109. [PubMed]
14. Rushton DH. Nutritional factors and hair loss. Clin Exp Dermatol. 2002;27:396–404. [PubMed]
15. Ead RD. Oral zinc sulphate in alopacia areata-a double blind trial. Br J Dermatol. 1981;104:483–484. [PubMed]
16. Cousins RJ. Absorption, transport, and hepatic metabolism of copper and zinc: special reference to metallothionein and ceruloplasmin. Physiol Rev. 1985;65:238–309. [PubMed]

Hair Loss Treatment, hair regrowth.

Hair Loss Treatment

Flores, et al. The longest telomeres: a general signature of adult stem cell compartments. Genes Dev. 2008; 22(5): 654–667

.....In summary, these findings demonstrate a hierarchical organization of cells of a common origin within tissues according to their telomere length in all organs examined so far (skin, small intestine, cornea, testis, and brain), with the longest telomeres generally marking the most primitive adult stem cell compartments and the shortest telomeres in the more differentiated compartments within a given tissue. Of note, the rate of telomere shortening within a given tissue appeared larger than expected from mere cell division, which may reflect on active telomere degradation mechanisms associated with differentiation, something that remains unexplored to date. Since cell hierarchies are general features of almost all adult organs, identification of the longest telomeres may represent a novel general marker of adult stem cell compartments, which combined with current ways to identify stem cells such as the so-called “label-retaining techniques” may be useful in identifying new stem cell compartments. Finally, we make the novel finding that Mus musculus telomeres shorten with age in all different stem cell compartments studied here, which in turn may result in decreased stem cell functionality at old age. The correct identification and characterization of adult stem cells in healthy and disease conditions could lead to new clinical applications, such as aid in their isolation as well in the study of their response to different treatments. In particular, tumors have been shown previously to show shorter telomeres compared with the normal surrounding tissue. The ability to identify different cell populations according to their telomere length within tumors will enable researchers to monitor their behavior in response to different stimuli or therapeutic treatments.

edited for hair loss treatment and hair regrowth blog use